Vancomycin: We Can't Get There From Here

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Vancomycin: we can't get there from here.

BACKGROUND We sought to characterize the pharmacodynamic profile of the more intensive vancomycin dosing regimens currently used in response to the recent vancomycin guidelines. METHODS A series of Monte Carlo simulations was performed for vancomycin regimens ranging from .5 g intravenous (IV) Q12H to 2 g IV Q12H. The probability of achieving an AUC/MIC ratio ≥ 400 for each dosing regimen was...

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ژورنال

عنوان ژورنال: Clinical Infectious Diseases

سال: 2011

ISSN: 1058-4838,1537-6591

DOI: 10.1093/cid/cir078